How skin bacteria influence skin health and healing
Microbial regulation of the keratinocyte AHR
This study is looking at how certain bacteria on our skin can help keep it healthy and heal better, especially for people with skin issues like atopic dermatitis, and it aims to find new treatments that use these helpful bacteria.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-11056034 on NIH RePORTER |
What this research studies
This research investigates the role of skin bacteria in maintaining skin health and healing, particularly focusing on a receptor in skin cells called the aryl hydrocarbon receptor (AHR). The study aims to identify specific microbial compounds that can activate this receptor to enhance skin barrier function and fight infections. By understanding how these bacteria interact with skin cells, the research seeks to develop new treatments for conditions like atopic dermatitis, which is characterized by skin barrier dysfunction and inflammation. Patients may be involved in trials testing these new microbial-based therapies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals suffering from atopic dermatitis or related skin conditions.
Not a fit: Patients with non-inflammatory skin conditions or those not affected by skin barrier dysfunction may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to innovative treatments that improve skin barrier function and reduce symptoms of atopic dermatitis.
How similar studies have performed: Previous research has shown promising results in understanding the role of skin microbiota in skin health, suggesting that this approach could lead to significant advancements in treatment.
Where this research is happening
Philadelphia, United States
- University of Pennsylvania — Philadelphia, United States (Active)
Researchers
- Principal investigator: Grice, Elizabeth Anne — University of Pennsylvania
- Study coordinator: Grice, Elizabeth Anne
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.