How SIRT6 helps keep our DNA and chromatin stable as we age
Regulation of epigenome stability by SIRT6 during Aging
['FUNDING_R37'] · UNIVERSITY OF ROCHESTER · NIH-11299583
Researchers are looking at how the protein SIRT6 protects DNA and chromatin during aging to help guide future ways to slow age-related decline.
Quick facts
| Phase | ['FUNDING_R37'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF ROCHESTER (nih funded) |
| Locations | 1 site (ROCHESTER, UNITED STATES) |
| Trial ID | NIH-11299583 on ClinicalTrials.gov |
What this research studies
This project focuses on a protein called SIRT6 that appears to help maintain the structure of our DNA and chromatin as organisms get older. Scientists will use cells and mouse models, compare normal and altered SIRT6 function, and study two biochemical activities of the protein (deacetylation and mono-ADP ribosylation). They will measure DNA repair, control of mobile genetic elements, and chromatin accessibility using techniques such as ATAC-seq and biochemical assays. The goal is to map how SIRT6 keeps the epigenome stable so findings can inform future therapies.
Who could benefit from this research
Good fit: Ideal candidates would be older adults willing to donate blood or tissue samples for aging and epigenetics research, if human samples are part of the project.
Not a fit: People seeking immediate clinical treatments or younger healthy individuals are unlikely to receive direct medical benefit from this primarily lab-based research.
Why it matters
Potential benefit: If successful, this work could point to new ways to preserve genome stability and reduce age-related tissue decline or diseases.
How similar studies have performed: Prior animal and cellular studies have shown SIRT6 affects DNA repair and that increasing SIRT6 can extend mouse lifespan, but applying this to human therapies remains unproven.
Where this research is happening
ROCHESTER, UNITED STATES
- UNIVERSITY OF ROCHESTER — ROCHESTER, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SELUANOV, ANDREI — UNIVERSITY OF ROCHESTER
- Study coordinator: SELUANOV, ANDREI
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.