How Sirt6 affects T cell metabolism and immune functions in cancer treatment
Epigenetic Regulation of T Cell Metabolism and Immune Functions by Sirt6
This study is looking at how a protein called Sirt6 affects the way T cells use energy and fight cancer, with the goal of finding ways to boost their effectiveness in cancer treatments.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Jacksonville NIH-funded |
| Lab location | 1 site (Jacksonville, United States) |
| Project ID | NIH-11031444 on NIH RePORTER |
What this research studies
This research investigates the role of Sirt6, an epigenetic regulator, in T cell metabolism and immune functions, particularly in the context of cancer immunotherapy. It aims to understand how Sirt6 influences the metabolic switch in T cells from oxidative phosphorylation to aerobic glycolysis, which is crucial for their activation and effectiveness against tumors. By exploring the mechanisms that lead to compromised T cell metabolism in the tumor microenvironment, the study seeks to identify strategies to enhance T cell responses and improve cancer treatment outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research are cancer patients who are currently undergoing or considering immunotherapy but have shown limited response to existing treatments.
Not a fit: Patients with non-cancerous conditions or those who are not receiving immunotherapy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved cancer immunotherapy by enhancing the effectiveness of T cells in attacking tumors.
How similar studies have performed: Other research has shown promising results in enhancing T cell functions through metabolic interventions, suggesting that this approach may lead to significant advancements in cancer treatment.
Where this research is happening
Jacksonville, United States
- Mayo Clinic Jacksonville — Jacksonville, United States (Active)
Researchers
- Principal investigator: Hamaidi, Imene — Mayo Clinic Jacksonville
- Study coordinator: Hamaidi, Imene
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.