How SIRT6 affects lifespan in fruit flies
Official title: Mechanisms of Lifespan Regulation by Sirt6 in Drosophila melanogaster
Funded at Cleveland State University · NIH-11046692 · Data updated 2026-11-12
This study is looking at how a protein called SIRT6 affects aging and lifespan in fruit flies, to help us understand how it might influence age-related diseases and which parts of the body it impacts.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cleveland State University NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project start | September 1, 2018 |
| Project end | February 28, 2026 |
| Funding year | 2025 |
| Award (this year) | $238,268 |
| NIH project number | 5R00AG057812-05 |
| Project ID | NIH-11046692 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for potential benefit include older adults experiencing age-related health issues.
✕Less likely to help
Patients with non-age-related conditions or those who are not elderly may not receive benefits from this research.
What this research studies
This research investigates the role of the SIRT6 protein in regulating lifespan, using fruit flies as a model organism. By manipulating the activity of SIRT6, the researchers aim to understand how it influences aging and age-related diseases. The study will explore which tissues are affected by SIRT6 and how its functions contribute to lifespan extension. Through advanced techniques like RNA sequencing and chromatin accessibility analysis, the research seeks to uncover the molecular mechanisms behind aging.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that extend healthy lifespan and treat age-related diseases in humans.
How similar studies have gone: Previous research has shown that manipulating SIRT6 can extend lifespan in mice, suggesting a promising avenue for similar approaches in humans.
Where this research is happening
-
Cleveland State University
Cleveland, United States Active
Researchers
- Principal investigator: Taylor, Jackson Richard — Cleveland State University
- Study coordinator: Taylor, Jackson Richard
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.