How simvastatin affects uterine fibroids
Mechanisms of actions(s) of simvastatin in uterine leiomyoma
['FUNDING_R01'] · JOHNS HOPKINS UNIVERSITY · NIH-10470204
This study is looking at how simvastatin, a cholesterol-lowering medication, might help women with uterine fibroids by slowing their growth and easing symptoms, and it aims to find out how it works and if it can be used with other treatments.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | JOHNS HOPKINS UNIVERSITY (nih funded) |
| Locations | 1 site (BALTIMORE, UNITED STATES) |
| Trial ID | NIH-10470204 on ClinicalTrials.gov |
What this research studies
This research investigates the effects of simvastatin, a medication commonly used to lower cholesterol, on uterine fibroids, which are non-cancerous tumors in the female reproductive system. The study aims to understand how simvastatin can inhibit the growth of these fibroids and alleviate related symptoms. Researchers will explore the mechanisms by which simvastatin operates, particularly its interaction with hormonal pathways and its potential to work alongside other treatments. By using both laboratory models and patient-derived samples, the research seeks to provide insights into a new non-hormonal treatment option for women suffering from uterine fibroids.
Who could benefit from this research
Good fit: Ideal candidates for this research are women diagnosed with uterine fibroids who are seeking alternative treatment options beyond hormonal therapies.
Not a fit: Patients who do not have uterine fibroids or those who are not seeking treatment for this condition may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to a new, effective non-hormonal treatment for uterine fibroids, improving the quality of life for many women.
How similar studies have performed: Previous studies have shown promising results with statins in reducing fibroid symptoms, indicating potential for success in this research.
Where this research is happening
BALTIMORE, UNITED STATES
- JOHNS HOPKINS UNIVERSITY — BALTIMORE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BORAHAY, MOSTAFA A. — JOHNS HOPKINS UNIVERSITY
- Study coordinator: BORAHAY, MOSTAFA A.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.