How signals in human tissues control immune responses of T cells
Metabolite- and cytokine-mediated signals interact to control human CD8 T cell responses in tissues
This study is looking at how different signals in the body affect the behavior of a type of immune cell called CD8 T cells, which are important for fighting infections, and it aims to help improve treatments for various health conditions by understanding how these cells work in both healthy and infected tissues.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Fred Hutchinson Cancer Center NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project ID | NIH-11072342 on NIH RePORTER |
What this research studies
This research investigates how various signals, including metabolites and cytokines, influence the behavior of CD8 T cells in human tissues. By examining both healthy and acutely infected tissues, the study aims to identify the activating and inhibitory signals that regulate T cell responses. The research utilizes advanced techniques such as ATAC sequencing to analyze the chromatin accessibility of T cells, providing insights into their functional regulation. This understanding could lead to improved strategies for modulating immune responses in various conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with acute infections or those undergoing treatment for conditions that affect T cell responses.
Not a fit: Patients with chronic, stable conditions that do not involve acute immune responses may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of immune regulation, potentially leading to better treatments for infections and autoimmune diseases.
How similar studies have performed: Previous research has shown that understanding immune signaling in animal models can lead to breakthroughs in human therapies, suggesting potential success for this novel approach.
Where this research is happening
Seattle, United States
- Fred Hutchinson Cancer Center — Seattle, United States (Active)
Researchers
- Principal investigator: Prlic, Martin — Fred Hutchinson Cancer Center
- Study coordinator: Prlic, Martin
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.