How signals in human tissues control immune responses of T cells
Official title: Metabolite- and cytokine-mediated signals interact to control human CD8 T cell responses in tissues
Funded at Fred Hutchinson Cancer Center · NIH-11072342 · Data updated 2026-11-12
This study is looking at how different signals in the body affect the behavior of a type of immune cell called CD8 T cells, which are important for fighting infections, and it aims to help improve treatments for various health conditions by understanding how these cells work in both healthy and infected tissues.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Fred Hutchinson Cancer Center NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project start | January 17, 2025 |
| Project end | December 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $857,346 |
| NIH project number | 1R01AI179712-01A1 |
| Project ID | NIH-11072342 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with acute infections or those undergoing treatment for conditions that affect T cell responses.
✕Less likely to help
Patients with chronic, stable conditions that do not involve acute immune responses may not benefit from this research.
What this research studies
This research investigates how various signals, including metabolites and cytokines, influence the behavior of CD8 T cells in human tissues. By examining both healthy and acutely infected tissues, the study aims to identify the activating and inhibitory signals that regulate T cell responses. The research utilizes advanced techniques such as ATAC sequencing to analyze the chromatin accessibility of T cells, providing insights into their functional regulation. This understanding could lead to improved strategies for modulating immune responses in various conditions.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of immune regulation, potentially leading to better treatments for infections and autoimmune diseases.
How similar studies have gone: Previous research has shown that understanding immune signaling in animal models can lead to breakthroughs in human therapies, suggesting potential success for this novel approach.
Where this research is happening
-
Fred Hutchinson Cancer Center
Seattle, United States Active
Researchers
- Principal investigator: Prlic, Martin — Fred Hutchinson Cancer Center
- Study coordinator: Prlic, Martin
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.