How signals in cells affect the development of nerve cells and their organization.
Polarity Signals Coordinate Neuronal Differentiation & Nuclear Organization
This study looks at how certain proteins help nerve cells grow and organize themselves, which could help us understand more about developmental disorders and childhood cancers.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | St. Jude Children's Research Hospital NIH-funded |
| Lab location | 1 site (Memphis, United States) |
| Project ID | NIH-11073623 on NIH RePORTER |
What this research studies
This research investigates how specific proteins influence the development and organization of nerve cells during their formation. By examining the roles of proteins that control the direction nerve cells migrate and how they organize their genetic material, the study aims to uncover mechanisms that could lead to better understanding of developmental disorders and pediatric cancers. The approach combines genetic techniques in living organisms with laboratory studies to explore these cellular processes in detail.
Who could benefit from this research
Good fit: Ideal candidates for this research are children with developmental disorders or pediatric cancers that involve compromised neuronal differentiation.
Not a fit: Patients with adult-onset neurological conditions or those without any neurological or developmental disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for developmental disorders and cancers affecting children by enhancing our understanding of neuronal differentiation.
How similar studies have performed: Previous research has shown promising results in understanding neuronal development through similar cellular signaling approaches, indicating a potential for success in this area.
Where this research is happening
Memphis, United States
- St. Jude Children's Research Hospital — Memphis, United States (Active)
Researchers
- Principal investigator: Solecki, David Joseph — St. Jude Children's Research Hospital
- Study coordinator: Solecki, David Joseph
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.