How signals in cells affect the development of nerve cells and their organization.
Official title: Polarity Signals Coordinate Neuronal Differentiation & Nuclear Organization
Funded at St. Jude Children's Research Hospital · NIH-11073623 · Data updated 2026-11-12
This study looks at how certain proteins help nerve cells grow and organize themselves, which could help us understand more about developmental disorders and childhood cancers.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | St. Jude Children's Research Hospital NIH-funded |
| Lab location | 1 site (Memphis, United States) |
| Project start | January 1, 2025 |
| Project end | December 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $676,388 |
| NIH project number | 1R01NS139519-01A1 |
| Project ID | NIH-11073623 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are children with developmental disorders or pediatric cancers that involve compromised neuronal differentiation.
✕Less likely to help
Patients with adult-onset neurological conditions or those without any neurological or developmental disorders may not benefit from this research.
What this research studies
This research investigates how specific proteins influence the development and organization of nerve cells during their formation. By examining the roles of proteins that control the direction nerve cells migrate and how they organize their genetic material, the study aims to uncover mechanisms that could lead to better understanding of developmental disorders and pediatric cancers. The approach combines genetic techniques in living organisms with laboratory studies to explore these cellular processes in detail.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for developmental disorders and cancers affecting children by enhancing our understanding of neuronal differentiation.
How similar studies have gone: Previous research has shown promising results in understanding neuronal development through similar cellular signaling approaches, indicating a potential for success in this area.
Where this research is happening
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St. Jude Children's Research Hospital
Memphis, United States Active
Researchers
- Principal investigator: Solecki, David Joseph — St. Jude Children's Research Hospital
- Study coordinator: Solecki, David Joseph
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.