How signals affect muscle stem cells during injury recovery
Official title: Regulation of Muscle Stem Cells by Netrin Signaling
Funded at Icahn School of Medicine at Mount Sinai · NIH-11143182 · Data updated 2026-11-12
This study is looking at how special muscle cells help heal injuries in our muscles and what makes them wake up and start working when we need repair, which could lead to new ways to help people recover from muscle damage.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | August 1, 2024 |
| Project end | May 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $180,323 |
| NIH project number | 5R21AR084632-02 |
| Project ID | NIH-11143182 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults over 21 years old who have experienced muscle injuries or conditions affecting muscle regeneration.
✕Less likely to help
Patients with chronic muscle diseases or those who do not have muscle injuries may not benefit from this research.
What this research studies
This research investigates the role of muscle stem cells (MuSCs) in the regeneration of skeletal muscle after injury. It focuses on understanding how these cells maintain a resting state (quiescence) and what triggers their activation to repair damaged muscle. The study will explore the cellular mechanisms and signals from the surrounding environment that influence MuSC behavior, particularly during the transition from quiescence to activation. By identifying these signals, the research aims to uncover new therapeutic targets for enhancing muscle repair.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for muscle injuries and degenerative conditions, enhancing recovery and muscle function.
How similar studies have gone: Previous research has shown promising results in understanding muscle stem cell dynamics, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Icahn School of Medicine at Mount Sinai
New York, United States Active
Researchers
- Principal investigator: Krauss, Robert S. — Icahn School of Medicine at Mount Sinai
- Study coordinator: Krauss, Robert S.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.