How SGLT2-blocking diabetes drugs affect kidney filtering and tubule function
Official title: Glomerular and Tubular Function in the Diabetic Kidney
Funded at Veterans Medical Research Fdn/san Diego · NIH-11324539 · Data updated 2026-11-12
This research looks at how SGLT2-blocking diabetes medicines change tiny blood vessels, tubules, and metabolism inside diabetic kidneys to explain how they slow kidney disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Veterans Medical Research Fdn/san Diego NIH-funded |
| Lab location | 1 site (San Diego, United States) |
| Project start | July 1, 2017 |
| Project end | March 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $475,065 |
| NIH project number | 5R01DK112042-09 |
| Project ID | NIH-11324539 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with type 2 diabetes, especially those with early or established diabetic kidney disease, could be asked to provide clinical samples or join related human studies.
✕Less likely to help
People without diabetes or whose kidney disease has a non-diabetic cause may not directly benefit from this specific work.
What this research studies
You should know the team is using mice and rats to look directly at microscopic parts of the kidney that can't be seen in people. They will examine how SGLT2-blocking drugs alter blood flow, oxygen delivery, and tubular function, and whether those changes protect against injury. The researchers will compare metabolite patterns from animal experiments with samples from people to find matching fingerprints. They will also explore whether targeting SGLT1 or off-target drug effects explain added benefits or risks.
Why it matters
Potential benefit: If successful, this work could clarify how SGLT2 drugs protect kidneys and point to new treatments to prevent or slow diabetic kidney failure.
How similar studies have gone: Large clinical trials have already shown SGLT2 blockers slow kidney decline in people with and without diabetes, but the microscopic mechanisms remain largely unproven.
Where this research is happening
-
Veterans Medical Research Fdn/san Diego
San Diego, United States Active
Researchers
- Principal investigator: Thomson, Scott Culver — Veterans Medical Research Fdn/san Diego
- Study coordinator: Thomson, Scott Culver
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.