How SGLT2-blocking diabetes drugs affect kidney filtering and tubule function
Glomerular and Tubular Function in the Diabetic Kidney
This research looks at how SGLT2-blocking diabetes medicines change tiny blood vessels, tubules, and metabolism inside diabetic kidneys to explain how they slow kidney disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Veterans Medical Research Fdn/san Diego NIH-funded |
| Lab location | 1 site (San Diego, United States) |
| Project ID | NIH-11324539 on NIH RePORTER |
What this research studies
You should know the team is using mice and rats to look directly at microscopic parts of the kidney that can't be seen in people. They will examine how SGLT2-blocking drugs alter blood flow, oxygen delivery, and tubular function, and whether those changes protect against injury. The researchers will compare metabolite patterns from animal experiments with samples from people to find matching fingerprints. They will also explore whether targeting SGLT1 or off-target drug effects explain added benefits or risks.
Who could benefit from this research
Good fit: Adults with type 2 diabetes, especially those with early or established diabetic kidney disease, could be asked to provide clinical samples or join related human studies.
Not a fit: People without diabetes or whose kidney disease has a non-diabetic cause may not directly benefit from this specific work.
Why it matters
Potential benefit: If successful, this work could clarify how SGLT2 drugs protect kidneys and point to new treatments to prevent or slow diabetic kidney failure.
How similar studies have performed: Large clinical trials have already shown SGLT2 blockers slow kidney decline in people with and without diabetes, but the microscopic mechanisms remain largely unproven.
Where this research is happening
San Diego, United States
- Veterans Medical Research Fdn/san Diego — San Diego, United States (Active)
Researchers
- Principal investigator: Thomson, Scott Culver — Veterans Medical Research Fdn/san Diego
- Study coordinator: Thomson, Scott Culver
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.