How sex hormones in the brain affect energy balance
Testosterone and estrogen signaling pathways in the medial amygdala interact to control energy homeostasis
This study is looking at how hormones like testosterone and estrogen affect energy use in the brain, which could help us find new ways to manage weight and metabolic issues for people.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Illinois at Chicago NIH-funded |
| Lab location | 1 site (Chicago, UNITED STATES) |
| Project ID | NIH-10931116 on NIH RePORTER |
What this research studies
This research investigates how sex hormones, specifically testosterone and estrogen, influence energy balance in the brain, particularly in the medial amygdala. By studying genetically modified mice, the researchers aim to understand how these hormones interact to regulate body weight and energy expenditure. The study focuses on the roles of specific receptors and enzymes involved in hormone signaling, which could provide insights into metabolic processes. Patients may benefit from findings that could lead to new treatments for weight management and metabolic disorders.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research would include individuals struggling with obesity or metabolic disorders influenced by hormonal imbalances.
Not a fit: Patients who do not have issues related to energy balance or hormonal regulation may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for managing obesity and related metabolic conditions.
How similar studies have performed: Other research has shown promising results in understanding hormone signaling pathways and their effects on metabolism, suggesting that this approach could yield valuable insights.
Where this research is happening
Chicago, UNITED STATES
- University of Illinois at Chicago — Chicago, United States (Active)
Researchers
- Principal investigator: Xu, Pingwen — University of Illinois at Chicago
- Study coordinator: Xu, Pingwen
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.