How sex hormones and chromosomes affect blood vessel health and aging
Interplay of Sex Hormones and Chromosomes in Vascular Oxidative Stress and Arterial Stiffening
This study is looking at how sex hormones and chromosomes affect heart and blood vessel health, especially in conditions like high blood pressure and stroke, using specially bred mice to learn more about these differences between men and women.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Augusta University NIH-funded |
| Lab location | 1 site (Augusta, United States) |
| Project ID | NIH-10885111 on NIH RePORTER |
What this research studies
This research investigates the role of sex hormones and chromosomes in cardiovascular disease, particularly focusing on how these factors contribute to vascular oxidative stress and arterial stiffness. The study will utilize advanced techniques and specially bred mice to explore the effects of sex chromosomes on blood vessel function in the absence of sex hormones. By understanding these mechanisms, the research aims to uncover new insights into how cardiovascular health differs between sexes, especially in conditions like hypertension and stroke.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with cardiovascular conditions, particularly those who may be affected by hypertension or stroke, and who are interested in understanding the role of sex differences in their health.
Not a fit: Patients without cardiovascular issues or those who do not identify with the sex differences being studied may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments and preventive strategies for cardiovascular diseases that take into account sex differences.
How similar studies have performed: While the impact of sex hormones on cardiovascular health is well-studied, the specific focus on sex chromosomes in this context is relatively novel and has not been extensively explored in previous research.
Where this research is happening
Augusta, United States
- Augusta University — Augusta, United States (Active)
Researchers
- Principal investigator: Ogola, Benard Ojwang — Augusta University
- Study coordinator: Ogola, Benard Ojwang
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.