How sex hormones affect stroke risk
The Role of Sex Hormones in Stroke Risk: A Sex-Specific Integrative Omics Analysis in the NHLBI Trans-Omics for Precision Medicine Cohorts
This project looks at whether sex hormones and related biological markers explain different stroke risks for adult women and men.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Vermont & St Agric College NIH-funded |
| Lab location | 1 site (Burlington, United States) |
| Project ID | NIH-11300743 on NIH RePORTER |
What this research studies
The team will use blood, genetic, and other biological data already collected from thousands of adults in large U.S. health cohorts to study how sex hormones and their biological pathways relate to future stroke risk. They will combine genomic, epigenomic, and metabolomic information with hormone measures like sex hormone binding globulin (SHBG) to find sex-specific factors linked to stroke. Using these findings they will create separate risk scores for women and men and test those scores in a large Brazilian cohort for validation. The work aims to point to biological targets and prediction tools that could eventually guide personalized stroke prevention.
Who could benefit from this research
Good fit: Ideal candidates are adults (age 21 and older) whose health or research data are part of TOPMed or similar cohort studies, especially people concerned about their stroke risk.
Not a fit: Children and people not represented in these cohorts (for example those under 21 or without hormone or genetic data) are unlikely to benefit directly from this project.
Why it matters
Potential benefit: If successful, this work could lead to sex-specific tools to better predict and prevent strokes.
How similar studies have performed: Previous studies have linked sex hormones to stroke risk, but integrating genomic, epigenomic, and metabolomic data to build sex-specific stroke prediction models is a newer approach.
Where this research is happening
Burlington, United States
- University of Vermont & St Agric College — Burlington, United States (Active)
Researchers
- Principal investigator: Madsen, Tracy — University of Vermont & St Agric College
- Study coordinator: Madsen, Tracy
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.