How sex hormones affect heart and metabolic health in people with diabetes
The Effect of Sex Hormones on Cardiometabolic Outcomes in Men and Women with Diabetes: The Look AHEAD (Action for Health in Diabetes) Study
This study is looking at how sex hormones affect heart and blood vessel health in men and women with type 2 diabetes, especially since women seem to have a higher risk of heart problems, and it hopes to find ways to improve diabetes care for everyone based on these differences.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-10884146 on NIH RePORTER |
What this research studies
This research investigates the impact of sex hormones on cardiometabolic outcomes in men and women with type 2 diabetes. It aims to understand why women with diabetes face higher risks of heart disease, stroke, and vascular dementia compared to men. By analyzing data from the Look AHEAD study, which involved lifestyle interventions for overweight individuals with diabetes, the research will explore how changes in weight and lifestyle may influence sex hormone levels and related health risks over time. The findings could lead to tailored interventions that consider sex differences in diabetes management.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults with type 2 diabetes, particularly those who are overweight or obese.
Not a fit: Patients without diabetes or those who are not overweight may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved diabetes management strategies that reduce cardiovascular risks, particularly for women.
How similar studies have performed: Previous studies have shown that lifestyle interventions can significantly impact health outcomes in diabetes, suggesting potential for success in this research.
Where this research is happening
Baltimore, United States
- Johns Hopkins University — Baltimore, United States (Active)
Researchers
- Principal investigator: Bennett, Wendy Lynet — Johns Hopkins University
- Study coordinator: Bennett, Wendy Lynet
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.