How sex hormones affect Chlamydia infections
Official title: The Effects of Sex Hormones on Chlamydia Infection
Funded at University of Maryland Baltimore · NIH-11290896 · Data updated 2026-11-12
This study is looking at how sex hormones and the bacteria in the vagina interact with Chlamydia infections, using a special model to better understand these relationships, which could help improve prevention and treatment for people dealing with Chlamydia.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Maryland Baltimore NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | April 1, 2025 |
| Project end | March 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $236,694 |
| NIH project number | 5U19AI158930-05 |
| Project ID | NIH-11290896 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals who are sexually active and may be at risk for Chlamydia infections, particularly those with varying levels of sex hormone exposure.
✕Less likely to help
Patients who are not sexually active or those who have no history of Chlamydia or related infections may not benefit from this research.
What this research studies
This research investigates the interactions between sex hormones, the cervicovaginal microbiota, and Chlamydia trachomatis infections. By developing a biomimetic model that mimics the cervicovaginal environment, the study aims to understand how these interactions influence the body's response to infection. The research employs advanced techniques such as global transcriptomics and immune profiling to gather comprehensive data on host and pathogen behavior. Patients may benefit from insights that could lead to improved prevention and treatment strategies for Chlamydia infections.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and management of Chlamydia infections, potentially improving treatment outcomes for affected patients.
How similar studies have gone: Previous research has shown promise in understanding host-pathogen interactions using biomimetic models, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Maryland Baltimore
Baltimore, United States Active
Researchers
- Principal investigator: Derre, Isabelle — University of Maryland Baltimore
- Study coordinator: Derre, Isabelle
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.