How sex hormones affect asthma differences between men and women
Gonadal hormones as mediators of sex and gender influences in asthma
This study is looking at how hormones, especially those related to sex, might affect asthma symptoms and severity in both women and men, including how hormone therapy for trans women could play a role, with the goal of finding new ways to help manage asthma.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Trustees of Indiana University NIH-funded |
| Lab location | 1 site (Bloomington, United States) |
| Project ID | NIH-11191143 on NIH RePORTER |
What this research studies
This research investigates the role of gonadal hormones in influencing asthma symptoms and severity, particularly focusing on how these hormones differ between sexes. It aims to understand the mechanisms by which female sex hormones, such as estrogens, may affect airway inflammation and reactivity in both women and men. The study will utilize experimental models to explore these hormonal effects, including the impact of feminizing hormone therapy in trans women. By examining these factors, the research seeks to uncover potential new treatment avenues for asthma based on hormonal influences.
Who could benefit from this research
Good fit: Ideal candidates for participation include adult women and trans women experiencing asthma symptoms.
Not a fit: Patients who are not affected by asthma or those who do not identify as female or trans may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more personalized and effective asthma treatments that consider hormonal influences.
How similar studies have performed: Previous studies have shown promising results regarding the influence of sex hormones on asthma, indicating that this research builds on established findings.
Where this research is happening
Bloomington, United States
- Trustees of Indiana University — Bloomington, United States (Active)
Researchers
- Principal investigator: Silveyra, Patricia — Trustees of Indiana University
- Study coordinator: Silveyra, Patricia
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.