How sex hormones affect asthma differences between men and women
Gonadal hormones as mediators of sex and gender influences in asthma
This study is looking at how hormones, especially those related to gender, affect asthma symptoms and severity, aiming to find better treatments for women and trans women who experience more asthma issues than men.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Trustees of Indiana University NIH-funded |
| Lab location | 1 site (Bloomington, United States) |
| Project ID | NIH-10891526 on NIH RePORTER |
What this research studies
This research investigates the role of gonadal hormones in influencing asthma symptoms and severity, particularly focusing on how these hormones differ between sexes. It aims to understand the mechanisms by which female sex hormones, such as estrogens, may contribute to increased asthma prevalence and exacerbations in women compared to men. The study will utilize experimental models to explore the effects of these hormones on lung inflammation and airway reactivity in both males and females, including the impact of hormone therapy in trans women. By examining these factors, the research seeks to uncover potential new treatment strategies tailored to gender-specific asthma responses.
Who could benefit from this research
Good fit: Ideal candidates for participation include adult women and trans women experiencing asthma symptoms, particularly those with severe or uncontrolled asthma.
Not a fit: Patients with asthma who are male or those who do not have a hormonal component to their asthma may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective, gender-specific treatments for asthma, improving outcomes for patients affected by this condition.
How similar studies have performed: Previous studies have shown success in understanding sex differences in asthma, but this specific approach focusing on hormonal influences is relatively novel.
Where this research is happening
Bloomington, United States
- Trustees of Indiana University — Bloomington, United States (Active)
Researchers
- Principal investigator: Silveyra, Patricia — Trustees of Indiana University
- Study coordinator: Silveyra, Patricia
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.