How sex differences affect obesity and heart disease prevention
Epigenetic sex determinants of cardiometabolic disease and prevention
['FUNDING_OTHER'] · UNIVERSITY OF CALIFORNIA LOS ANGELES · NIH-10919841
This study is looking at how being male or female affects the way our bodies handle weight and heart health, especially focusing on certain genes, and it hopes to help people understand how their sex might change their risk for heart problems and how well treatments work for them.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA LOS ANGELES (nih funded) |
| Locations | 1 site (LOS ANGELES, UNITED STATES) |
| Trial ID | NIH-10919841 on ClinicalTrials.gov |
What this research studies
This research investigates how biological sex influences the development of obesity and related heart diseases. It focuses on specific genes located on the sex chromosomes that differ in expression between males and females, affecting body fat and responses to statin medications. By using mouse models and human stem cells, the study aims to uncover the mechanisms behind these sex-specific differences in fat biology and drug response. Patients may benefit from a better understanding of how their sex impacts their risk for cardiometabolic diseases and treatment outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with obesity or cardiovascular disease, particularly those who have experienced adverse effects from statin medications.
Not a fit: Patients who do not have obesity or cardiovascular conditions, or those who are not affected by statin medications, may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more personalized prevention and treatment strategies for obesity and cardiovascular diseases based on a patient's sex.
How similar studies have performed: Previous research has shown that understanding sex differences in disease mechanisms can lead to significant advancements in treatment, suggesting this approach has potential for success.
Where this research is happening
LOS ANGELES, UNITED STATES
- UNIVERSITY OF CALIFORNIA LOS ANGELES — LOS ANGELES, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: REUE, KAREN — UNIVERSITY OF CALIFORNIA LOS ANGELES
- Study coordinator: REUE, KAREN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.