How sex differences affect immune responses in obesity and related conditions
Sex-dependent innate immune mechanisms in type 2 immunity and obesity
This study is looking at how being overweight affects the immune system differently in men and women, with the goal of finding new ways to help people with obesity and type 2 diabetes feel better and fight infections.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Riverside NIH-funded |
| Lab location | 1 site (Riverside, United States) |
| Project ID | NIH-11167066 on NIH RePORTER |
What this research studies
This research investigates how obesity influences the immune system, particularly focusing on the differences between male and female immune responses. It aims to understand the role of specific immune cells, such as macrophages and eosinophils, in mediating these responses and how they relate to obesity and type 2 diabetes. By studying these immune mechanisms, the research seeks to identify potential new treatments for metabolic disorders and infections caused by parasites. Patients may benefit from insights into how their sex may influence their immune response and treatment options.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with obesity, particularly those experiencing complications like type 2 diabetes or infections.
Not a fit: Patients who are not affected by obesity or related metabolic disorders may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments tailored to individual patients based on their sex and immune response.
How similar studies have performed: Previous research has shown that understanding immune responses can lead to significant advancements in treatment for metabolic disorders, suggesting this approach has potential for success.
Where this research is happening
Riverside, United States
- University of California Riverside — Riverside, United States (Active)
Researchers
- Principal investigator: Nair, Meera Goh — University of California Riverside
- Study coordinator: Nair, Meera Goh
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.