How sex differences affect glioblastoma growth
Sex-specific differences in the tumor microenvironment alter glioblastoma growth
This study is looking at how being male or female affects the growth of glioblastoma, a serious brain tumor, by exploring the differences in cells and the surrounding environment, which could help create better, personalized treatments for patients based on their sex.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cleveland Clinic Lerner Com-Cwru NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project ID | NIH-10916681 on NIH RePORTER |
What this research studies
This research investigates how biological differences between sexes influence the growth of glioblastoma, the most common malignant brain tumor. It examines both the internal cellular mechanisms and the external tumor microenvironment that differ between males and females. By utilizing advanced mouse models that closely mimic human glioblastoma, the study aims to uncover the roles of immune responses and genetic factors in tumor progression. The findings could lead to more tailored treatment approaches based on sex-specific characteristics.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with glioblastoma, particularly those who are male or female and may benefit from tailored therapies.
Not a fit: Patients with glioblastoma who do not have a clear sex-specific response to treatment may not receive significant benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies for glioblastoma that take into account sex-specific differences.
How similar studies have performed: Other research has shown promising results in understanding sex differences in various cancers, suggesting that this approach could yield valuable insights in glioblastoma as well.
Where this research is happening
Cleveland, United States
- Cleveland Clinic Lerner Com-Cwru — Cleveland, United States (Active)
Researchers
- Principal investigator: Silver, Daniel J — Cleveland Clinic Lerner Com-Cwru
- Study coordinator: Silver, Daniel J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.