How sex differences affect Alzheimer's disease progression
Impact of sex differences on the trajectory of interactome dysfunctions across the AD spectrum
This study is looking at how being male or female might affect the way Alzheimer's disease develops and gets worse by examining brain proteins, and it's for anyone interested in understanding more about how this condition impacts different people.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Sloan-Kettering Inst Can Research NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11090462 on NIH RePORTER |
What this research studies
This research investigates how sex differences influence the development and progression of Alzheimer's disease (AD) by examining protein interactions in the brain. Using advanced techniques called epichaperomics, the study aims to analyze postmortem human brain samples to identify changes in biological systems related to AD. By focusing on vulnerable brain regions, the research seeks to uncover the underlying mechanisms that contribute to the disease's trajectory and severity in different sexes. This approach combines high-throughput technologies with sophisticated computational methods to provide deeper insights into the molecular basis of AD.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Alzheimer's disease, particularly those who are willing to provide postmortem brain tissue samples.
Not a fit: Patients who do not have Alzheimer's disease or those who are not able to provide postmortem samples may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more personalized and effective treatments for Alzheimer's disease based on sex-specific biological insights.
How similar studies have performed: While the specific approach of epichaperomics is novel, there is growing evidence that understanding sex differences in Alzheimer's disease can lead to significant advancements in treatment strategies.
Where this research is happening
New York, United States
- Sloan-Kettering Inst Can Research — New York, United States (Active)
Researchers
- Principal investigator: Chiosis, Gabriela — Sloan-Kettering Inst Can Research
- Study coordinator: Chiosis, Gabriela
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.