How sex chromosomes and hormones influence inflammation in Alzheimer's disease
Official title: The developmental effects of sex chromosomes and hormones specify microglial inflammation in Alzheimer's diseaes
Funded at Northeast Ohio Medical University · NIH-10979172 · Data updated 2026-11-12
This study is looking at how Alzheimer's disease affects men and women differently, especially by exploring how their unique biology might influence brain inflammation, with the hope of finding new ways to treat or prevent the disease that could work better for each gender.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Northeast Ohio Medical University NIH-funded |
| Lab location | 1 site (Rootstown, United States) |
| Project start | February 1, 2022 |
| Project end | November 30, 2026 |
| Funding year | 2025 |
| Award (this year) | $351,000 |
| NIH project number | 5R01AG075897-04 |
| Project ID | NIH-10979172 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals at risk for Alzheimer's disease, particularly women, who may experience different disease progression due to hormonal and genetic factors.
✕Less likely to help
Patients who do not have Alzheimer's disease or related dementias may not receive direct benefits from this research.
What this research studies
This research investigates the biological differences in how Alzheimer's disease affects men and women, particularly focusing on the role of sex chromosomes and hormones in brain inflammation. By using a specific mouse model, the study aims to understand how these factors contribute to the inflammatory processes associated with Alzheimer's. The goal is to uncover mechanisms that could lead to new therapies for preventing and treating Alzheimer's disease and other related dementias. Patients may benefit from insights that could lead to gender-specific treatments in the future.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that are tailored to address the unique inflammatory responses in Alzheimer's disease for different sexes.
How similar studies have gone: While the specific approach of examining sex chromosomes and hormones in Alzheimer's is relatively novel, there is existing research indicating that sex differences play a significant role in the disease's progression.
Where this research is happening
-
Northeast Ohio Medical University
Rootstown, United States Active
Researchers
- Principal investigator: Reed, Erin G — Northeast Ohio Medical University
- Study coordinator: Reed, Erin G
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.