How severe infections affect brain health in older adults and those with Alzheimer's disease
Sepsis and the Systemic Cytokine Storm in Aging and Alzheimer Disease Models
This study looks at how serious infections like sepsis might affect brain health in older adults, especially those showing early signs of Alzheimer's, to see if the body's response to infection can lead to more memory problems down the line.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Florida NIH-funded |
| Lab location | 1 site (Gainesville, United States) |
| Project ID | NIH-10513525 on NIH RePORTER |
What this research studies
This research investigates the impact of severe infections, specifically sepsis, on cognitive decline in older adults, particularly those with early signs of Alzheimer's disease. It explores how a systemic inflammatory response, known as a cytokine storm, can persist even after the infection has resolved and potentially worsen brain health. The study uses animal models to examine the relationship between sepsis, neurodegeneration, and the accumulation of harmful proteins associated with Alzheimer's. By understanding these mechanisms, the research aims to identify how age and cognitive status influence the effects of sepsis on brain health.
Who could benefit from this research
Good fit: Ideal candidates for this research include older adults, especially those with early signs of Alzheimer's disease or those who have experienced severe infections.
Not a fit: Patients who are younger or do not have any cognitive impairments or history of severe infections may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or mitigating cognitive decline in older adults following severe infections.
How similar studies have performed: Previous research has shown that systemic inflammation can impact brain health, suggesting that this approach may yield valuable insights into cognitive decline.
Where this research is happening
Gainesville, United States
- University of Florida — Gainesville, United States (Active)
Researchers
- Principal investigator: Efron, Philip a — University of Florida
- Study coordinator: Efron, Philip a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.