How serotonin levels during development affect dopamine function
Modulation of serotonin levels during development produce long-lasting changes in dopaminergic function
['FUNDING_R01'] · NATHAN S. KLINE INSTITUTE FOR PSYCH RES · NIH-10609846
This study looks at how higher levels of serotonin during important growth stages can affect dopamine, which plays a big role in our mood and motivation, and it aims to help us understand how things like a mother's health and medications might impact behavior later in life.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | NATHAN S. KLINE INSTITUTE FOR PSYCH RES (nih funded) |
| Locations | 1 site (ORANGEBURG, UNITED STATES) |
| Trial ID | NIH-10609846 on ClinicalTrials.gov |
What this research studies
This research investigates how elevated serotonin levels during critical developmental periods can lead to long-lasting changes in dopamine function, which is crucial for mood and motivation. By examining the effects of serotonin on brain development, particularly in the context of maternal health and medication use, the study aims to understand the underlying mechanisms that may contribute to behavioral issues in adulthood. The research utilizes animal models to explore these relationships, focusing on the interactions between serotonin and dopamine systems. Findings could provide insights into how early environmental factors influence mental health outcomes later in life.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research are individuals with a history of mood disorders or those who have been exposed to high levels of serotonin during critical developmental periods.
Not a fit: Patients who do not have a history of mood disorders or who have not been exposed to serotonin-altering conditions may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and treatment of mood disorders and motivational deficits in adults.
How similar studies have performed: Other research has shown that manipulating serotonin levels during development can significantly impact brain function, suggesting that this approach may yield valuable insights.
Where this research is happening
ORANGEBURG, UNITED STATES
- NATHAN S. KLINE INSTITUTE FOR PSYCH RES — ORANGEBURG, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: TEIXEIRA, CATIA — NATHAN S. KLINE INSTITUTE FOR PSYCH RES
- Study coordinator: TEIXEIRA, CATIA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.