How serotonin affects brain development and connections in autism
Serotonergic modulation of excitatory synapse formation and maturation during development
['FUNDING_R01'] · UNIVERSITY OF COLORADO DENVER · NIH-11001205
This study is looking at how serotonin, a brain chemical, affects the growth and connections of brain cells in babies, especially in relation to Autism Spectrum Disorders, and it aims to find out if certain medications taken during pregnancy can change serotonin levels and impact brain development.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF COLORADO DENVER (nih funded) |
| Locations | 1 site (Aurora, UNITED STATES) |
| Trial ID | NIH-11001205 on ClinicalTrials.gov |
What this research studies
This research investigates the role of serotonin in the formation and maturation of synapses in the developing brain, particularly in relation to Autism Spectrum Disorders (ASDs). It aims to understand how exposure to certain drugs during pregnancy can influence serotonin levels and potentially lead to neurodevelopmental issues. By studying animal models, the research seeks to uncover the basic mechanisms by which serotonin modulates brain function and impacts the establishment of neural circuits. The findings could provide insights into the environmental factors that contribute to ASDs and how synaptic development is affected.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Autism Spectrum Disorders or those at risk due to prenatal exposure to serotonin-altering medications.
Not a fit: Patients who do not have Autism Spectrum Disorders or related neurodevelopmental conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and potential interventions for Autism Spectrum Disorders, improving outcomes for affected individuals.
How similar studies have performed: Previous research has shown promising results in understanding the role of serotonin in neurodevelopment, suggesting that this approach could yield valuable insights.
Where this research is happening
Aurora, UNITED STATES
- UNIVERSITY OF COLORADO DENVER — Aurora, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: OH, WON CHAN — UNIVERSITY OF COLORADO DENVER
- Study coordinator: OH, WON CHAN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.