How sensory nerves affect bone metastasis and pain in cancer
The contributions of sensory nerves to bone metastasis and associated bone pain
['FUNDING_R01'] · WAKE FOREST UNIVERSITY HEALTH SCIENCES · NIH-10794304
This study is looking at how nerves in the body might affect pain and the spread of prostate cancer to the bones, with the hope of finding new ways to help manage pain and improve treatment for patients dealing with this issue.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | WAKE FOREST UNIVERSITY HEALTH SCIENCES (nih funded) |
| Locations | 1 site (WINSTON-SALEM, UNITED STATES) |
| Trial ID | NIH-10794304 on ClinicalTrials.gov |
What this research studies
This research investigates the role of sensory nerves in the development of bone metastasis and the associated pain experienced by patients with prostate cancer. The team is exploring how cancer cells that spread to the bone can influence nerve growth and pain signaling through specific neuropeptides. By studying these mechanisms in mice, the researchers aim to uncover potential targets for new treatments that could alleviate pain and improve outcomes for patients with bone metastases.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients with prostate cancer who have developed bone metastases and are experiencing bone pain.
Not a fit: Patients without prostate cancer or those whose cancer has not metastasized to the bone may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that reduce bone pain and improve the quality of life for patients with metastatic prostate cancer.
How similar studies have performed: Other research has indicated that targeting nerve signaling pathways can be effective in managing cancer-related pain, suggesting that this approach may hold promise.
Where this research is happening
WINSTON-SALEM, UNITED STATES
- WAKE FOREST UNIVERSITY HEALTH SCIENCES — WINSTON-SALEM, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SHIOZAWA, YUSUKE — WAKE FOREST UNIVERSITY HEALTH SCIENCES
- Study coordinator: SHIOZAWA, YUSUKE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: bone disorder, Bone Diseases, Cancers, neoplasm/cancer