How sensory nerves affect blood flow and inflammation in inflammatory bowel disease
Role of sensory nerves in perivascular inflammation and vasomotor dysfunction with inflammatory bowel disease
This study is looking at how nerves in the body help control blood flow and inflammation in people with inflammatory bowel disease (IBD), to better understand how these nerves might affect heart health during flare-ups.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Missouri-Columbia NIH-funded |
| Lab location | 1 site (Columbia, United States) |
| Project ID | NIH-11046634 on NIH RePORTER |
What this research studies
This research investigates the role of sensory nerves in regulating blood flow and inflammation in patients with inflammatory bowel disease (IBD). It focuses on how these nerves interact with blood vessels and surrounding tissues, particularly during episodes of inflammation. By studying the mechanisms involved, the research aims to uncover how nerve signaling can influence blood flow and potentially contribute to cardiovascular issues associated with IBD. The approach includes examining the effects of specific neuropeptides and immune cells on blood vessel function in the context of IBD.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with inflammatory bowel disease who may also experience cardiovascular complications.
Not a fit: Patients without inflammatory bowel disease or those with unrelated gastrointestinal conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve blood flow and reduce inflammation in patients with inflammatory bowel disease.
How similar studies have performed: Previous research has shown that targeting sensory nerves and their signaling pathways can improve vascular function in other inflammatory conditions, suggesting potential for success in this area as well.
Where this research is happening
Columbia, United States
- University of Missouri-Columbia — Columbia, United States (Active)
Researchers
- Principal investigator: Boerman, Erika Mary — University of Missouri-Columbia
- Study coordinator: Boerman, Erika Mary
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.