How semen helps the body accept a fetus during pregnancy
The role of semen in induction of paternal-specific tolerance during pregnancy
This study is looking at how being exposed to a partner's semen before getting pregnant might help a woman's body accept the baby by understanding how certain immune cells work, which could lead to healthier pregnancies and help prevent issues like preeclampsia.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Washington NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project ID | NIH-10778534 on NIH RePORTER |
What this research studies
This research investigates how exposure to semen before conception may help a woman's immune system tolerate the paternal antigens present in the fetus. It focuses on the role of regulatory T cells (Tregs) and antigen-presenting cells (APCs) in developing this tolerance. By analyzing how semen components influence these immune cells, the study aims to understand the mechanisms that promote a healthy pregnancy and how complications like preeclampsia may arise. The research employs advanced techniques to assess immune responses in vaginal and cervical tissues.
Who could benefit from this research
Good fit: Ideal candidates for this research are women who are planning to conceive and are interested in understanding factors that may influence pregnancy outcomes.
Not a fit: Patients who are not planning to conceive or those with existing severe pregnancy complications may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for managing pregnancy complications and enhancing maternal-fetal tolerance.
How similar studies have performed: While the specific approach of this research is novel, there is existing evidence suggesting that immune tolerance mechanisms are crucial for successful pregnancies.
Where this research is happening
Seattle, United States
- University of Washington — Seattle, United States (Active)
Researchers
- Principal investigator: Vojtech, Lucia N — University of Washington
- Study coordinator: Vojtech, Lucia N
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.