How selenium enzymes that control thyroid hormones are broken down in cells
Selenodeidinase Processing by the Proteasome System
This work looks at how cells modify and remove enzymes that change thyroid hormones, which could help people with thyroid-related problems.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Med Br Galveston NIH-funded |
| Lab location | 1 site (Galveston, United States) |
| Project ID | NIH-11269295 on NIH RePORTER |
What this research studies
You would be told that the team will study how deiodinase enzymes, which turn thyroid hormone on or off inside cells, are chemically modified and processed by the cell's proteasome system. They will perform laboratory experiments in cells (and possibly tissue samples) to track those enzyme changes, block or alter the proteasome, and measure resulting effects on intracellular thyroid hormone levels and signaling. Learning these steps may explain why some tissues have too much or too little thyroid hormone activity even when blood tests look normal. The research is lab-based and aims to point toward future diagnostic or treatment strategies for thyroid disorders.
Who could benefit from this research
Good fit: People with thyroid disorders—such as unexplained hypothyroidism, hyperthyroidism, or abnormal tissue-specific thyroid hormone effects—would be the most likely candidates for related clinical follow-up studies.
Not a fit: Patients with conditions unrelated to thyroid hormone regulation or those needing immediate clinical treatment are unlikely to benefit directly from this basic laboratory research.
Why it matters
Potential benefit: If successful, this work could reveal new ways to fix abnormal local thyroid hormone activity and lead to better tests or treatments for thyroid conditions.
How similar studies have performed: Previous lab studies have shown that deiodinases are regulated by cellular degradation pathways, but the detailed mechanisms of proteasome processing of selenodeiodinases remain incompletely understood.
Where this research is happening
Galveston, United States
- University of Texas Med Br Galveston — Galveston, United States (Active)
Researchers
- Principal investigator: Bianco, Antonio C — University of Texas Med Br Galveston
- Study coordinator: Bianco, Antonio C
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.