How Schwann cell problems affect nerve structure and function
Official title: Impact of Schwann Cell Pathology on Axon Structure and Function
Funded at New York University School of Medicine · NIH-11014994 · Data updated 2026-11-12
This study looks at how certain cells in your nerves work with nerve fibers to create and maintain the protective covering around them, which is important for people with Charcot-Marie-Tooth disorders that affect movement and sensation.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York University School of Medicine NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | December 1, 2022 |
| Project end | November 30, 2027 |
| Funding year | 2025 |
| Award (this year) | $464,148 |
| NIH project number | 5R01NS130035-03 |
| Project ID | NIH-11014994 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Charcot-Marie-Tooth disorders or related conditions that affect nerve myelination.
✕Less likely to help
Patients with conditions unrelated to Schwann cell pathology or those without neurological symptoms may not benefit from this research.
What this research studies
This research investigates the interactions between Schwann cells and axons, which are crucial for the formation and maintenance of myelinated nerves. It focuses on how signals from axons and the surrounding environment influence Schwann cells to produce myelin, the protective sheath around nerves. By understanding these processes, the research aims to uncover the underlying mechanisms of Charcot-Marie-Tooth disorders, which can lead to significant neurological disabilities. The study employs various biological techniques to analyze the effects of Schwann cell pathology on nerve function.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for Charcot-Marie-Tooth disorders and improve nerve function in affected patients.
How similar studies have gone: Previous research has shown promising results in understanding Schwann cell interactions and their impact on nerve function, indicating that this approach has potential for success.
Where this research is happening
-
New York University School of Medicine
New York, United States Active
Researchers
- Principal investigator: Salzer, James — New York University School of Medicine
- Study coordinator: Salzer, James
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.