How schistosome infections affect metabolism in immune cells
Durable Schistosome induced metabolic alterations to the myeloid lineage
['FUNDING_R01'] · UNIVERSITY OF UTAH · NIH-10769777
This study is looking at how being exposed to certain parasites might help improve the immune system and protect against heart problems and insulin resistance in people with diabetes, using mice to learn more about how this works and what could lead to new treatments for patients.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF UTAH (nih funded) |
| Locations | 1 site (SALT LAKE CITY, UNITED STATES) |
| Trial ID | NIH-10769777 on ClinicalTrials.gov |
What this research studies
This research investigates how exposure to schistosome parasites can lead to long-lasting changes in immune cells, particularly monocytes and macrophages, which may help protect against insulin resistance and cardiovascular disease in diabetic patients. By studying these changes, the researchers aim to understand how schistosome infections might alter the metabolism of fats and other substances in the body. The project will utilize mouse models to explore these metabolic pathways and identify potential genetic factors that contribute to this protective effect. Ultimately, the goal is to develop new therapies that could benefit diabetic patients at risk for heart disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are diabetic patients who are at risk for cardiovascular complications.
Not a fit: Patients who are not diabetic or do not have cardiovascular risk factors may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to innovative treatments that reduce the risk of cardiovascular disease in diabetic patients.
How similar studies have performed: There is emerging evidence suggesting that chronic helminth infections may have protective effects against metabolic syndrome, indicating a promising area of research.
Where this research is happening
SALT LAKE CITY, UNITED STATES
- UNIVERSITY OF UTAH — SALT LAKE CITY, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: FAIRFAX, KEKE CELESTE — UNIVERSITY OF UTAH
- Study coordinator: FAIRFAX, KEKE CELESTE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.