How SARS-CoV2 affects protein production in human cells
Mechanisms of SARS-CoV2 translation initiation and shut-off of cellular protein synthesis
This study looks at how the SARS-CoV2 virus tricks our cells into making its own proteins while stopping our bodies from fighting it off, and by learning more about this process, researchers hope to find new ways to help treat COVID-19.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Suny Downstate Medical Center NIH-funded |
| Lab location | 1 site (Brooklyn, United States) |
| Project ID | NIH-10609872 on NIH RePORTER |
What this research studies
This research investigates how the SARS-CoV2 virus manipulates the host cell's machinery to produce its own proteins while shutting down the production of the host's proteins. It focuses on the mechanisms by which the virus suppresses the host's immune responses and selectively allows its own mRNA to be translated. By understanding these processes, researchers aim to identify potential therapeutic targets that could inhibit the virus's ability to replicate and cause disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals infected with SARS-CoV2 or those at high risk of COVID-19 complications.
Not a fit: Patients who are not infected with SARS-CoV2 or who have already recovered from COVID-19 may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of new treatments that effectively combat COVID-19 by targeting the virus's ability to hijack cellular processes.
How similar studies have performed: Other research has shown promise in targeting viral mechanisms in similar ways, indicating that this approach could lead to significant advancements in treatment.
Where this research is happening
Brooklyn, United States
- Suny Downstate Medical Center — Brooklyn, United States (Active)
Researchers
- Principal investigator: Hellen, Christopher Ulrich Tristram — Suny Downstate Medical Center
- Study coordinator: Hellen, Christopher Ulrich Tristram
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.