How SARS-CoV-2 infection affects blood clotting
Cellular effects of SARS-CoV-2 in mediating thrombotic susceptibility
This study is looking at how the COVID-19 virus can cause problems like blood clots and inflammation in the body, and it aims to find specific markers in the blood of patients that could help create better treatments to prevent these serious issues.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Iowa NIH-funded |
| Lab location | 1 site (Iowa City, United States) |
| Project ID | NIH-11002291 on NIH RePORTER |
What this research studies
This research investigates the cellular mechanisms by which SARS-CoV-2, the virus responsible for COVID-19, leads to increased blood clotting and inflammation. It focuses on understanding how certain proteins and immune cells become activated during infection, potentially causing complications like thrombosis. By analyzing plasma samples from COVID-19 patients, the study aims to identify specific biomarkers and pathways that contribute to these thrombotic events. This could help in developing targeted treatments to prevent severe complications in infected individuals.
Who could benefit from this research
Good fit: Ideal candidates for this research include hospitalized patients diagnosed with COVID-19 who are at risk of developing thrombotic complications.
Not a fit: Patients who have recovered from COVID-19 and are no longer experiencing symptoms may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments that reduce the risk of blood clots in COVID-19 patients.
How similar studies have performed: Other research has shown promising results in understanding thrombotic complications in COVID-19, suggesting that this approach could yield valuable insights.
Where this research is happening
Iowa City, United States
- University of Iowa — Iowa City, United States (Active)
Researchers
- Principal investigator: Dayal, Sanjana — University of Iowa
- Study coordinator: Dayal, Sanjana
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.