How SARS-CoV-2 copies its genetic code and where drugs can block it
Structure, function, and inhibition of the SARS-CoV-2 replication-transcription complex
Researchers are making highly detailed 3D maps of the virus's copying machinery to find spots where antiviral drugs could block COVID-19.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rockefeller University NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11184511 on NIH RePORTER |
What this research studies
Scientists will take high-resolution structural images of the virus's RNA polymerase and its partner proteins to see exactly how they work together to copy the viral genome. They will examine how the antiviral remdesivir and other molecules interact with the complex before they are incorporated into viral RNA. The team will combine these structures with biochemical experiments to identify vulnerable sites where drugs can bind. Those structural models will be shared with drug developers to guide the design of new antiviral compounds.
Who could benefit from this research
Good fit: This grant does not enroll patients directly, but its findings aim to help people with active or recent SARS‑CoV‑2 infection who might receive improved antivirals in the future.
Not a fit: People without SARS‑CoV‑2 infection or those whose symptoms are driven mainly by immune reactions rather than active viral replication may not see direct benefit from these structural studies.
Why it matters
Potential benefit: If successful, this work could enable design of more effective antiviral medicines that shorten illness and reduce severe COVID-19.
How similar studies have performed: High-resolution structures of the coronavirus polymerase have already helped explain how remdesivir works, but using such models to create new, more effective drugs is promising yet still emerging.
Where this research is happening
New York, United States
- Rockefeller University — New York, United States (Active)
Researchers
- Principal investigator: Darst, Seth a. — Rockefeller University
- Study coordinator: Darst, Seth a.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.