How salt-sensitive hypertension affects cognitive impairment in dementia
Neuroimmune Mechanisms of Cognitive Impairment in Salt-sensitive Hypertension
['FUNDING_OTHER'] · VANDERBILT UNIVERSITY MEDICAL CENTER · NIH-10909297
This study is looking at how salt in your diet might affect blood pressure and thinking skills in people with Alzheimer's disease, focusing on how a specific immune response could harm your brain and blood vessels.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | VANDERBILT UNIVERSITY MEDICAL CENTER (nih funded) |
| Locations | 1 site (NASHVILLE, UNITED STATES) |
| Trial ID | NIH-10909297 on ClinicalTrials.gov |
What this research studies
This research investigates the connection between salt-sensitive hypertension and cognitive impairment in patients with dementia, particularly Alzheimer's disease. It aims to understand how dietary salt influences immune responses, specifically the role of interleukin-17 (IL17) in damaging blood vessels and neurons. By examining how IL17 affects both endothelial cells and immune cells in the brain, the study seeks to uncover mechanisms that lead to cognitive decline. Patients may be involved in assessments that explore these neuroimmune interactions and their impact on cognitive health.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults over 21 years old who have been diagnosed with hypertension and exhibit signs of cognitive impairment or dementia.
Not a fit: Patients without hypertension or those who do not have any form of cognitive impairment or dementia may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating cognitive impairment in patients with hypertension and dementia.
How similar studies have performed: Previous research has indicated that immune responses play a significant role in cognitive decline, suggesting that this approach may yield valuable insights.
Where this research is happening
NASHVILLE, UNITED STATES
- VANDERBILT UNIVERSITY MEDICAL CENTER — NASHVILLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SANTISTEBAN, MONICA M — VANDERBILT UNIVERSITY MEDICAL CENTER
- Study coordinator: SANTISTEBAN, MONICA M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alzheimer disease dementia, Alzheimer syndrome