How Salmonella uses energy in the inflamed gut
Central metabolism of Salmonella in the inflamed gut
Finding out whether blocking the way Salmonella gets energy in inflamed intestines can reduce gut infection and symptoms in people with non-typhoidal Salmonella.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California at Davis NIH-funded |
| Lab location | 1 site (Davis, United States) |
| Project ID | NIH-11241041 on NIH RePORTER |
What this research studies
Researchers use a mouse model that mimics human Salmonella-caused ileitis with neutrophil-rich inflammation. They will map which carbon sources and energy pathways Salmonella relies on in the inflamed ileum. Then they will test drugs that block anaerobic respiration to see if this reduces bacterial growth, disease severity, and fecal shedding. Findings may point to new treatment strategies to limit infection and transmission.
Who could benefit from this research
Good fit: Patients with acute non-typhoidal Salmonella intestinal infection, especially those with inflammation of the terminal ileum (ileitis), would be the most relevant group for future clinical testing.
Not a fit: People with typhoidal Salmonella, non-bacterial causes of diarrhea, or asymptomatic carriers may not benefit from the approaches in this grant.
Why it matters
Potential benefit: Could point to new treatments that reduce Salmonella growth, lessen symptoms, and lower spread to others.
How similar studies have performed: Prior mouse colitis studies have shown that inflammation-driven metabolic changes support Salmonella in the large intestine, but applying metabolic inhibition to ileitis and testing drug approaches is relatively novel.
Where this research is happening
Davis, United States
- University of California at Davis — Davis, United States (Active)
Researchers
- Principal investigator: Winter, Sebastian E — University of California at Davis
- Study coordinator: Winter, Sebastian E
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.