How Salmonella interacts with beneficial E. coli in the gut
Metabolic Interactions between Salmonella and E. coli Nissle 1917
This study is looking at how a helpful type of E. coli can stop Salmonella from causing problems in the gut by competing for important nutrients, and it's designed for anyone interested in improving gut health and fighting infections.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California at Davis NIH-funded |
| Lab location | 1 site (Davis, United States) |
| Project ID | NIH-10663378 on NIH RePORTER |
What this research studies
This research investigates the interactions between Salmonella enterica and a beneficial strain of E. coli known as Nissle 1917 in the intestinal tract. It aims to understand how E. coli Nissle 1917 can prevent Salmonella from colonizing the gut and causing inflammation by competing for essential nutrients like nitrate. The study will utilize mouse models and laboratory techniques to explore the mechanisms behind this competition and the role of iron acquisition in this process. By uncovering these interactions, the research seeks to enhance our understanding of gut health and pathogen resistance.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with gastrointestinal issues or those at risk of Salmonella infections.
Not a fit: Patients with no history of gastrointestinal infections or those who do not have a microbiota imbalance may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating infections caused by Salmonella.
How similar studies have performed: Previous research has shown that probiotic strains can effectively compete with pathogens in the gut, suggesting that this approach may yield promising results.
Where this research is happening
Davis, United States
- University of California at Davis — Davis, United States (Active)
Researchers
- Principal investigator: Winter, Sebastian E — University of California at Davis
- Study coordinator: Winter, Sebastian E
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.