How Salmonella disrupts gut bacteria during infection
Mechanisms of Salmonella-mediated disruption of colonization resistance in the inflamed gut
This study is looking at how the Salmonella bacteria can upset the healthy balance of good bacteria in your gut when you’re infected, and it aims to help us understand how Salmonella manages to survive and grow during inflammation.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University Medical Center NIH-funded |
| Lab location | 1 site (Nashville, United States) |
| Project ID | NIH-10885987 on NIH RePORTER |
What this research studies
This research investigates how the bacteria Salmonella enterica serovar Typhimurium disrupts the natural balance of gut bacteria during infection. It focuses on understanding the mechanisms by which Salmonella overcomes the protective effects of beneficial gut microbiota, particularly during inflammation. The study will explore how Salmonella uses specific systems to invade gut cells and utilize inflammation-related resources to thrive. By examining these interactions, the research aims to shed light on the complex dynamics between pathogens and the gut ecosystem.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have experienced gastrointestinal infections, particularly those caused by Salmonella.
Not a fit: Patients with non-infectious gastrointestinal disorders or those not affected by Salmonella may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating Salmonella infections and improving gut health.
How similar studies have performed: Other research has shown success in understanding gut microbiota interactions with pathogens, indicating that this approach has potential for meaningful insights.
Where this research is happening
Nashville, United States
- Vanderbilt University Medical Center — Nashville, United States (Active)
Researchers
- Principal investigator: Byndloss, Mariana Xavier — Vanderbilt University Medical Center
- Study coordinator: Byndloss, Mariana Xavier
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.