How Salmonella changes signals inside human cells
Host Cell Signaling Pathways Induced by Salmonella
['FUNDING_R01'] · YALE UNIVERSITY · NIH-11321644
This work looks at how Salmonella bacteria alter the signaling inside human cells in ways that help the bacteria survive and spread, with the goal of helping people who get Salmonella infections.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | YALE UNIVERSITY (nih funded) |
| Locations | 1 site (NEW HAVEN, UNITED STATES) |
| Trial ID | NIH-11321644 on ClinicalTrials.gov |
What this research studies
Researchers focus on how different Salmonella types use molecular secretion systems to send bacterial effector proteins into host cells and change cell behavior. They study effects on the actin cytoskeleton, gene expression, vesicle traffic, and immune responses that let Salmonella enter and replicate in cells. The team uses laboratory cell models, animal models, and gene-editing tools like CRISPR to pinpoint which host pathways are targeted. Findings are intended to reveal new targets for therapies or vaccines against Salmonella infections.
Who could benefit from this research
Good fit: People who have had confirmed Salmonella infection or typhoid fever, or who are willing to provide clinical samples for research, would be the most relevant participants.
Not a fit: People with illnesses unrelated to Salmonella or those not willing to provide samples are unlikely to receive direct benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could point to new treatments or vaccines that prevent or reduce the severity of Salmonella infections.
How similar studies have performed: Previous research has identified many Salmonella secretion systems and effectors, but turning that knowledge into new therapies has been limited, so this work builds on established biology to fill remaining gaps.
Where this research is happening
NEW HAVEN, UNITED STATES
- YALE UNIVERSITY — NEW HAVEN, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: GALAN, JORGE E — YALE UNIVERSITY
- Study coordinator: GALAN, JORGE E
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.