How Salmonella breaks down the gut's natural defenses
Mechanisms of Salmonella-mediated disruption of colonization resistance in the inflamed gut
Researchers are finding how Salmonella upsets healthy gut bacteria so the infection can take hold, to help people with Salmonella-related diarrhea.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University Medical Center NIH-funded |
| Lab location | 1 site (Nashville, United States) |
| Project ID | NIH-11133064 on NIH RePORTER |
What this research studies
If you get Salmonella gut infection, this project aims to explain how the bacteria upset your normal gut microbes and cause diarrhea. Researchers will use laboratory models and microbial samples to see how Salmonella-triggered inflammation changes the gut ecosystem. They will study how the pathogen resists inhibitory compounds made by healthy bacteria and how it uses inflammation-derived chemicals to grow. Understanding these steps could point to new ways to stop Salmonella from taking over the gut.
Who could benefit from this research
Good fit: People who have had or are at risk for non-typhoidal Salmonella infection or who are willing to provide stool or related samples for research would be ideal candidates.
Not a fit: Patients with health issues unrelated to gut infections or those seeking immediate clinical treatment are unlikely to get direct benefits from this laboratory-focused research.
Why it matters
Potential benefit: Could lead to new treatments or preventive strategies that stop Salmonella from overpowering healthy gut bacteria and reduce the severity or duration of diarrheal illness.
How similar studies have performed: Previous work has shown Salmonella can exploit inflammation-derived compounds to grow in the gut, and this project builds on those findings to identify additional mechanisms.
Where this research is happening
Nashville, United States
- Vanderbilt University Medical Center — Nashville, United States (Active)
Researchers
- Principal investigator: Byndloss, Mariana Xavier — Vanderbilt University Medical Center
- Study coordinator: Byndloss, Mariana Xavier
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.