How Salmonella bacteria interact with immune cells
Official title: Salmonella Interactions with Macrophages
Funded at Stanford University · NIH-11131209 · Data updated 2026-11-12
This study is looking at how typhoidal Salmonella bacteria manage to survive and grow inside immune cells that are supposed to fight infections, which could help us find better ways to treat enteric fever.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project start | July 3, 2024 |
| Project end | May 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $771,495 |
| NIH project number | 5R01AI179893-02 |
| Project ID | NIH-11131209 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who have been diagnosed with enteric fever or are at high risk of infection due to exposure to typhoidal Salmonella.
✕Less likely to help
Patients with non-typhoidal Salmonella infections or those who do not have any history of enteric fever may not benefit from this research.
What this research studies
This research investigates the interactions between typhoidal Salmonella bacteria and macrophages, which are immune cells that play a crucial role in fighting infections. By using advanced techniques like random barcode transposon-site sequencing and genomic comparisons, the study aims to uncover how these bacteria evade the immune response and thrive within these cells. The researchers will analyze gene expression and identify specific traits that contribute to the bacteria's ability to cause disease. This work could lead to a better understanding of enteric fever and potential new treatments.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for enteric fever, reducing morbidity and mortality associated with these infections.
How similar studies have gone: Previous research has shown success in understanding bacterial interactions with immune cells, but this specific focus on typhoidal Salmonella is relatively novel.
Where this research is happening
-
Stanford University
Stanford, United States Active
Researchers
- Principal investigator: Monack, Denise M — Stanford University
- Study coordinator: Monack, Denise M
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.