How Salmonella bacteria compete with gut microbes during infection
Mechanisms of Microbial Competition During Salmonella Infection
This study looks at how Salmonella bacteria can survive in the gut even when there are helpful microbes around that usually keep infections at bay, and it aims to find out how these bacteria manage to thrive, which could help us develop better treatments for infections.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California at Davis NIH-funded |
| Lab location | 1 site (Davis, United States) |
| Project ID | NIH-10984466 on NIH RePORTER |
What this research studies
This research investigates how Salmonella bacteria manage to thrive in the gut despite the presence of beneficial microbes that usually protect against infections. By studying an animal model, the researchers aim to understand the mechanisms that allow Salmonella to overcome the protective effects of short-chain fatty acids produced by gut bacteria. The study focuses on the role of specific metabolic pathways in Salmonella's ability to grow in a hostile environment, which could lead to new insights into bacterial infections and treatments.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who are at risk of Salmonella infections, particularly those with compromised gut microbiota.
Not a fit: Patients who are not affected by Salmonella infections or have no risk factors for such infections may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating Salmonella infections by targeting its growth mechanisms.
How similar studies have performed: Other research has shown success in understanding microbial interactions in the gut, but this specific approach to studying Salmonella's competition with gut microbes is relatively novel.
Where this research is happening
Davis, United States
- University of California at Davis — Davis, United States (Active)
Researchers
- Principal investigator: Radlinski, Lauren Christine — University of California at Davis
- Study coordinator: Radlinski, Lauren Christine
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.