How Salmonella bacteria compete with gut microbes during infection
Official title: Mechanisms of Microbial Competition During Salmonella Infection
Funded at University of California at Davis · NIH-10984466 · Data updated 2026-11-12
This study looks at how Salmonella bacteria can survive in the gut even when there are helpful microbes around that usually keep infections at bay, and it aims to find out how these bacteria manage to thrive, which could help us develop better treatments for infections.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California at Davis NIH-funded |
| Lab location | 1 site (Davis, United States) |
| Project start | December 1, 2022 |
| Project end | November 30, 2025 |
| Funding year | 2025 |
| Award (this year) | $78,892 |
| NIH project number | 5F32AI169649-03 |
| Project ID | NIH-10984466 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who are at risk of Salmonella infections, particularly those with compromised gut microbiota.
✕Less likely to help
Patients who are not affected by Salmonella infections or have no risk factors for such infections may not benefit from this research.
What this research studies
This research investigates how Salmonella bacteria manage to thrive in the gut despite the presence of beneficial microbes that usually protect against infections. By studying an animal model, the researchers aim to understand the mechanisms that allow Salmonella to overcome the protective effects of short-chain fatty acids produced by gut bacteria. The study focuses on the role of specific metabolic pathways in Salmonella's ability to grow in a hostile environment, which could lead to new insights into bacterial infections and treatments.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating Salmonella infections by targeting its growth mechanisms.
How similar studies have gone: Other research has shown success in understanding microbial interactions in the gut, but this specific approach to studying Salmonella's competition with gut microbes is relatively novel.
Where this research is happening
-
University of California at Davis
Davis, United States Active
Researchers
- Principal investigator: Radlinski, Lauren Christine — University of California at Davis
- Study coordinator: Radlinski, Lauren Christine
Related research
Other NIH-funded projects on the same topics.
-
UC Davis IGA Innovation Center
A research center at UC Davis will study gene-edited livestock to improve animal health, safety, and policy through sharing genetic data and findings about genome edits in cattle, pigs, sheep, and goats.
-
Administrative Core of an equitable breast cancer screening program
A national program headed from UC Davis is coordinating several research efforts to improve how breast cancer screening is done in community settings.
-
The role of novelty and surprise in learning for people with Alzheimer’s disease
A study explores how surprising events affect memory and learning in people related to Alzheimer’s disease, using everyday tasks to see how the brain remembers new information.
-
Understanding how distraction affects students and how to measure it better
This grant studies why distracted students, including those with ADHD, struggle in real-life learning and tests a clearer way to measure distraction in everyday settings.
-
California Partnership for Personalized Nutrition
A California clinical center is testing personalized dietary approaches to improve blood sugar and health for adults with diabetes by using big data and AI to tailor meals.
-
Advancing gastric cancer care for Latinos through patient-derived tumor models
Aimed at Latinos with gastric cancer, this project uses patient-derived tumor models to study how cancer biology and treatments work in real tumors.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.