How S100A12 protein affects immune response and inflammation during infections
Official title: Interdependence of Antimicrobial and Pro-inflammatory Activities Mediated by S100A12 in the Innate Immune Response
Funded at College of Staten Island · NIH-10438080 · Data updated 2026-11-12
This study is looking at a protein called S100A12 to see how it helps our immune system fight infections and manage inflammation, especially by interacting with nutrients like zinc and calcium, which could lead to better ways to treat infections and inflammatory diseases.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | College of Staten Island NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | August 1, 2019 |
| Project end | August 31, 2025 |
| Funding year | 2022 |
| Award (this year) | $471,269 |
| NIH project number | 2R15GM131338-02 |
| Project ID | NIH-10438080 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with infections or inflammatory conditions that may involve the immune system.
✕Less likely to help
Patients with non-infectious diseases or those not experiencing inflammation may not benefit from this research.
What this research studies
This research investigates the role of the S100A12 protein in the immune response, particularly how it interacts with nutrients and receptors during infections. By studying the molecular interactions of S100A12, the research aims to understand how it can both fight infections and trigger inflammation. The approach includes examining how S100A12 binds to metals like zinc and calcium, which may influence its function in the immune system. This could lead to new insights into managing infections and inflammatory diseases.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that enhance the body's ability to fight infections while managing inflammation.
How similar studies have gone: Previous research has shown that understanding protein interactions in the immune system can lead to significant advancements in treatment strategies, suggesting this approach has potential for success.
Where this research is happening
-
College of Staten Island
New York, United States Active
Researchers
- Principal investigator: Gupta, Rupal — College of Staten Island
- Study coordinator: Gupta, Rupal
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.