How rotavirus uses calcium signaling to replicate and affect cells
Enteric virus exploitation of calcium signaling
['FUNDING_R01'] · BAYLOR COLLEGE OF MEDICINE · NIH-10914313
This study is looking at how the rotavirus, which causes bad diarrhea in kids, uses calcium signals in our cells to help it spread, and by figuring this out, researchers hope to find new ways to stop the virus from doing its damage.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BAYLOR COLLEGE OF MEDICINE (nih funded) |
| Locations | 1 site (HOUSTON, UNITED STATES) |
| Trial ID | NIH-10914313 on ClinicalTrials.gov |
What this research studies
This research investigates how rotavirus, a leading cause of severe diarrhea in children, manipulates calcium signaling in cells to enhance its replication. The study focuses on a specific type of calcium signal called intercellular calcium waves, which are triggered by infected cells and affect neighboring uninfected cells. By understanding these mechanisms, the research aims to identify potential therapeutic targets to disrupt the virus's ability to exploit these signaling pathways. The approach includes examining the biochemical interactions and cellular responses involved in this process.
Who could benefit from this research
Good fit: Ideal candidates for this research are children under 5 years old who are at risk of rotavirus infection or have experienced acute gastroenteritis.
Not a fit: Patients who are older than 11 years or those who do not have rotavirus infections may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new antiviral therapies that reduce the severity of rotavirus infections in children.
How similar studies have performed: Other research has shown success in targeting viral exploitation of cellular signaling pathways, suggesting that this approach may yield valuable insights.
Where this research is happening
HOUSTON, UNITED STATES
- BAYLOR COLLEGE OF MEDICINE — HOUSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: HYSER, JOSEPH M. — BAYLOR COLLEGE OF MEDICINE
- Study coordinator: HYSER, JOSEPH M.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.