How RNAs on neutrophil surfaces affect immune responses
The role of cell surface RNAs in neutrophils
['FUNDING_R01'] · YALE UNIVERSITY · NIH-11239775
The team will see whether RNAs on the surface of neutrophils help these immune cells attach to blood vessels and respond to inflammation.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | YALE UNIVERSITY (nih funded) |
| Locations | 1 site (NEW HAVEN, UNITED STATES) |
| Trial ID | NIH-11239775 on ClinicalTrials.gov |
What this research studies
This work looks for sugar-tagged RNAs (called glycoRNAs) on the outside of neutrophils and studies what they do. Scientists will isolate neutrophils and use biochemical tests and imaging to identify and characterize these surface RNAs. They will test how changing these RNAs alters neutrophil interactions with blood vessel cells and movement into tissues. The goal is to understand basic steps that control inflammation so future treatments can target those steps.
Who could benefit from this research
Good fit: People with inflammatory or vascular conditions, or healthy volunteers willing to donate blood for neutrophil samples, would be the most relevant participants for sample-based parts of this work.
Not a fit: Patients seeking an immediate new treatment are unlikely to benefit directly because this is early, basic research rather than a clinical therapy.
Why it matters
Potential benefit: If successful, this could reveal new targets to control excessive inflammation or improve how immune cells move to injured tissues.
How similar studies have performed: This is a largely new and exploratory area—only a few early reports describe glycoRNAs on cell surfaces, so the approach is novel rather than already proven.
Where this research is happening
NEW HAVEN, UNITED STATES
- YALE UNIVERSITY — NEW HAVEN, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LU, JUN — YALE UNIVERSITY
- Study coordinator: LU, JUN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.