How RNA viruses manipulate the immune system using host chemokines
RNA virus capture of host chemokines: Understanding novel viral mechanisms of immune manipulation
This study is looking at how a new virus called Jeremy Point virus tricks our immune system by grabbing onto certain signals that help our body fight infections, and it's for anyone interested in understanding how viruses work and how we might find new ways to treat them.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Florida NIH-funded |
| Lab location | 1 site (Gainesville, United States) |
| Project ID | NIH-10551229 on NIH RePORTER |
What this research studies
This research investigates how certain RNA viruses, which can cause serious diseases in humans and animals, manipulate the immune system by capturing host chemokines. The study focuses on a newly discovered virus, Jeremy Point virus (JPTV), and aims to understand how it uses these captured genes to recruit immune cells to infection sites. Researchers will employ advanced techniques such as reverse genetics and microfluidics to explore the functionality of these viral proteins. By uncovering these mechanisms, the research seeks to provide insights into viral behavior and potential therapeutic targets.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have been affected by or are at risk of infections caused by RNA viruses, such as influenza or Zika.
Not a fit: Patients who are not affected by RNA viruses or do not have related health conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating diseases caused by RNA viruses.
How similar studies have performed: Other research has shown success in understanding viral mechanisms of immune manipulation, indicating that this approach has potential for significant findings.
Where this research is happening
Gainesville, United States
- University of Florida — Gainesville, United States (Active)
Researchers
- Principal investigator: Allison, Andrew Brownell — University of Florida
- Study coordinator: Allison, Andrew Brownell
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.