How RNA structure influences gene expression in bacteria
Official title: Post-transcription Initiation Control of Gene Expression
Funded at Pennsylvania State University, the · NIH-10839515 · Data updated 2026-11-12
This study looks at how the structure of RNA helps control gene activity in bacteria, like E. coli and Bacillus subtilis, and aims to find new ways to develop antibiotics or treatments for bacterial infections that could help patients.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Pennsylvania State University, the NIH-funded |
| Lab location | 1 site (University Park, United States) |
| Project start | September 1, 2024 |
| Project end | August 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $239,962 |
| NIH project number | 1R35GM153190-01 |
| Project ID | NIH-10839515 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research would include individuals with bacterial infections or those interested in the mechanisms of antibiotic resistance.
✕Less likely to help
Patients with viral infections or non-bacterial diseases may not receive any benefit from this research.
What this research studies
This research investigates the role of RNA structure in regulating gene expression during transcription in bacteria, specifically focusing on Escherichia coli and Bacillus subtilis. By examining how RNA polymerase activity and ribosome access to mRNA are affected, the study aims to uncover critical mechanisms that control gene expression. The research employs advanced techniques like RNET-seq and cryo-electron microscopy to analyze the interactions between transcription factors and RNA. Patients may benefit from insights gained into bacterial gene regulation, which could inform the development of new antibiotics or treatments for bacterial infections.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating bacterial infections by targeting gene expression mechanisms.
How similar studies have gone: Other research has shown success in understanding bacterial gene regulation, making this approach promising but still exploring novel aspects.
Where this research is happening
-
Pennsylvania State University, the
University Park, United States Active
Researchers
- Principal investigator: Babitzke, Paul L — Pennsylvania State University, the
- Study coordinator: Babitzke, Paul L
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.