How RNA shapes control cell processes
Role of structural dynamics in RNA regulation
This project explores how the shapes of messenger RNA (mRNA) molecules in our cells direct important processes, and how changes in these shapes can lead to various human diseases.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Baylor College of Medicine NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-11123342 on NIH RePORTER |
What this research studies
Our bodies rely on messenger RNA (mRNA) to carry instructions for making proteins, and specific regions of mRNA called 3'UTRs contain vital instructions that control when and how these proteins are made. When these instructions are disrupted, it can contribute to many different human diseases. This project aims to understand how the unique shapes and structures of these 3'UTR regions guide these instructions, acting like switches that turn cell processes on or off. We are using a new technology called DANCE-MaP to precisely map these RNA shapes and how they change within living cells. By learning more about these structures, we hope to uncover new ways to understand and potentially address diseases linked to faulty RNA regulation.
Who could benefit from this research
Good fit: This foundational research does not directly involve patient participation, but future studies building on this knowledge could benefit patients with diseases linked to RNA regulation issues.
Not a fit: Patients seeking immediate treatment or direct clinical intervention would not receive direct benefit from this basic science project.
Why it matters
Potential benefit: If successful, this work could lead to a deeper understanding of disease mechanisms and potentially identify new targets for therapies that correct faulty RNA regulation.
How similar studies have performed: While the specific DANCE-MaP technology is novel, the broader field of RNA structural biology has shown promise in revealing fundamental mechanisms relevant to disease.
Where this research is happening
Houston, United States
- Baylor College of Medicine — Houston, United States (Active)
Researchers
- Principal investigator: Mustoe, Anthony Mcdowell — Baylor College of Medicine
- Study coordinator: Mustoe, Anthony Mcdowell
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.