How RNA differences affect our health and diseases
Understanding how structural mutations and individual RNA isoforms are involved in human health and disease
This project aims to understand how tiny differences in our genetic instructions, called RNA isoforms, contribute to human health and various diseases.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Kentucky NIH-funded |
| Lab location | 1 site (Lexington, United States) |
| Project ID | NIH-11089841 on NIH RePORTER |
What this research studies
Our bodies are incredibly complex, and while we know a lot about our genes, we're still learning about the many variations of genetic instructions, called RNA and protein isoforms, that each gene can produce. These variations might explain why people respond differently to medicines, why diseases develop, or even differences between sexes. We are using advanced technology to look closely at these individual RNA variations to discover their specific roles in human health and disease.
Who could benefit from this research
Good fit: This foundational research does not directly involve patient participation but seeks to understand the biological mechanisms underlying human health and disease.
Not a fit: Patients seeking immediate new treatments or direct clinical intervention would not find direct benefit from this basic science project.
Why it matters
Potential benefit: If successful, this work could lead to a deeper understanding of human biology, paving the way for more personalized and effective treatments for a wide range of diseases.
How similar studies have performed: While the concept of RNA isoforms is established, this project employs advanced long-read sequencing to explore individual isoform functions in human health and disease, representing a novel and in-depth approach.
Where this research is happening
Lexington, United States
- University of Kentucky — Lexington, United States (Active)
Researchers
- Principal investigator: Ebbert, Mark T W — University of Kentucky
- Study coordinator: Ebbert, Mark T W
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.