How RNA controls memory and brain function
RNA Control of Neural Function
This work looks at how RNA molecules in the brain influence learning, memory, and conditions like Fragile X and autism.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of Massachusetts Med Sch Worcester NIH-funded |
| Lab location | 1 site (Worcester, United States) |
| Project ID | NIH-11311807 on NIH RePORTER |
What this research studies
Researchers study molecules that control when and how brain cells make proteins, focusing on two key RNA‑binding proteins called CPEB1 and FMRP. They use molecular lab work, recordings of brain cell activity, and animal behavior tests to see how changes in RNA control affect synapses, learning, and memory. The team also examines how mis‑regulated RNA leads to altered splicing and RNA breakdown that can contribute to neurodevelopmental and neurodegenerative problems. Findings aim to link basic molecular changes to behavioral and cognitive effects relevant to autism and related conditions.
Who could benefit from this research
Good fit: People with autism spectrum disorder, Fragile X syndrome, or related learning and memory difficulties would be most directly interested in following and possibly participating in related future studies.
Not a fit: Those without neurological or developmental brain conditions are unlikely to gain direct benefit from this basic laboratory research in the short term.
Why it matters
Potential benefit: If successful, this research could point to new molecular targets that someday improve learning, memory, or symptoms linked to Fragile X and autism.
How similar studies have performed: Previous molecular and animal studies have linked CPEB1 and FMRP to memory and autism‑like behaviors, but translating these findings into human treatments remains in early stages.
Where this research is happening
Worcester, United States
- Univ of Massachusetts Med Sch Worcester — Worcester, United States (Active)
Researchers
- Principal investigator: Richter, Joel D — Univ of Massachusetts Med Sch Worcester
- Study coordinator: Richter, Joel D
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.