How RNA controls allergic airway inflammation
RNA regulatory circuits in allergic airway inflammation
Learning how RNA-based switches in immune and airway cells keep allergic asthma symptoms going for people with type 2 (allergic) asthma.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project ID | NIH-11387456 on NIH RePORTER |
What this research studies
Researchers are studying RNA 'switches' that help immune T cells and airway lining cells keep allergic inflammation turned on. They focus on 3' untranslated regions (3'UTRs) of messenger RNA and the RNA-binding proteins that control how long inflammatory messages stick around. The work uses laboratory models of airway and immune cells to map the circuits that stabilize or degrade these messages. Discovering these circuits could point to new ways to stop long-lasting allergic inflammation and reduce asthma flare-ups.
Who could benefit from this research
Good fit: People with allergic, type 2 asthma (airway inflammation driven by IL-4/IL-13 and Th2 cells) are the most relevant group for this research.
Not a fit: People whose asthma is non-allergic (non–type 2) or whose breathing problems are due to other lung diseases may be less likely to benefit from findings focused on T2 inflammation.
Why it matters
Potential benefit: If successful, this work could identify new targets to reduce persistent allergic inflammation and lower the frequency or severity of asthma attacks.
How similar studies have performed: Laboratory studies have shown RNA-binding proteins can control inflammatory responses, but applying 3'UTR-focused RNA circuit mapping specifically to persistent T2 asthma is relatively new.
Where this research is happening
San Francisco, United States
- University of California, San Francisco — San Francisco, United States (Active)
Researchers
- Principal investigator: Garudadri, Suresh — University of California, San Francisco
- Study coordinator: Garudadri, Suresh
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.